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Final Program


CRS Abstract Guide

Nanomedicine and Nanoscale Delivery

Bioengineering

Tech Session III: Nanomedicine and Nanoscale Delivery (Bioengineering)

Fabrication and evaluation of calcium polyphosphate-based graft materials for spinal fusion

Wednesday, July 16, 2025
11:27 AM - 11:38 AM EDT
Location: 120 B/C
Introduction: Spinal fusions are among the most common clinical scenarios that involve bone graft procedures [1]. Despite advances in surgery and bone grafts, success rates are low and there is a need for revision surgery. The average revision surgery costs $41,631 to the healthcare system. [2]. Autogenous iliac crest bone graft (ICBG) is the gold standard, but its restricted availability necessitates synthetic alternatives. Calcium polyphosphate nanoparticles (Ca-PolyP-NPs) are angiogenic and osteogenic [3], but spinal fusion evaluations have not been evaluated, which is the goal of this investigation.

Learning Objectives:

At the completion of this activity, participants will know
  • Understanding in the advancement in the procedures and graft materials for spinal fusion.
  • Understanding the desired properties of graft materials.
  • About bone formation using graft materials in a murine model of posterior lumbar spinal fusion.
Duby Okonkwo – Graduate student, Vanderbilt University; Jonathan G. Schoenecker – Associate Professor, Vanderbilt Center for Bone Biology (VCBB); Jason R. McCarthy – Associate Professor, Masonic Medical Research Institute