Tech Session III: Nanomedicine and Nanoscale Delivery (Bioengineering)
Apigenin-loaded nanoparticles for obesity intervention through immunomodulation
Wednesday, July 16, 2025
11:38 AM – 11:49 AM EDT
Introduction: Obesity is a global health crisis linked to inflammation and metabolic dysfunction. Adipose tissue (AT) remodeling in obesity involves macrophage imbalance, with pro-inflammatory M1 macrophages inhibiting AT browning and worsening insulin resistance. Apigenin (Api), a flavonoid, promotes M2 polarization and AT browning but has poor bioavailability. To enhance its effects, we developed Api-loaded PLGA nanoparticles (Api-NPs). In HFD-induced obese mice, Api-NPs reduced inflammation, shifted macrophages toward M2, and promoted AT browning, offering a potential obesity treatment.
Learning Objectives:
At the completion of this activity, participants will know
Upon completion, participants will be able to describe macrophage polarization and Api-NP therapy.
Upon completion, participants will be able to define macrophage polarization in obesity.
Upon completion, participants will be able to demonstrate the effects of Api-NPs on inflammation.
