Tech Session IV: Alternative Methods to Animal Testing I
Genomic Instability and Shear Stress Influence Nanoparticle-Induced Endothelial Cell Responses
Wednesday, July 16, 2025
3:38 PM – 3:49 PM EDT
Introduction: Little is known about endothelial cell responses to nanoparticles under conditions simulating dysfunctional endothelium, in conditions of aging and cancer, namely shear stress on the endothelial cells due to blood flow and endothelial cell cycle abnormalities [1, 2]. This work addresses this gap by exploring the effects of shear stress and endothelial chromosomal abnormalities on endothelial cell-level and RNA-level responses to two types of quantum dots (QDs): CdSe/ZnS and InP/ZnS QDs.
Learning Objectives:
At the completion of this activity, participants will know
Demonstrate the importance of organ-on-a-chip technology in modeling biological microenvironments.
Dynamic flow and cell cycle stress are crucial parameters to consider in evaluating novel therapies.
