Bioinspired Peptide-Based Materials for Regenerative Therapies

The development of advanced biomaterials that mimic natural systems offers effective solutions for challenges in regenerative medicine and targeted drug delivery. In this work, we present a series of bioinspired nanotechnologies based on peptide-based and hybrid self-assembling materials, engineered for controlled release, biocompatibility, and functional integration with host tissues. These systems exhibit tunable mechanical and electrical properties, respond to physiological stimuli, and support cellular adhesion, proliferation, and differentiation. Special emphasis is placed on their applications in bone and skin tissue regeneration, where they promote vascularization, integration with the native extracellular matrix, and sustained therapeutic delivery. Our multidisciplinary approach, spanning materials science, nanotechnology, and biomedical engineering, resulted in the development of innovative therapeutic platforms supported by both in vitro and in vivo studies. This work underscores the translational impact of nature-inspired materials in precision medicine and functional tissue repair.