Magneto-responsive drug delivery systems for local treatment of colorectal cancer

This presentation introduces two magneto-responsive systems designed for localized treatment of colorectal cancer (CRC), aiming to overcome the limitations of conventional therapies. We engineered superparamagnetic iron oxide nanoparticle (SPION)-loaded wax capsules for ultrasound-guided, magnetically-triggered drug delivery to the colon. Furthermore, we developed a thermo-responsive magnetic hydrogel for rectal tumor ablation, which transitions from liquid to gel upon contact with body temperature and enables localized heating under an alternating magnetic field. The talk will cover nanoparticle production, formulation development, in vitro, ex vivo and in vivo performance, and the potential for precise, minimally invasive CRC therapy with reduced systemic toxicity and improved patient compliance.

Learning Objectives:
- Explore the use of SPIONs in site-specific and magnetically responsive oral formulations
- Learn how magnetic, thermo-responsive hydrogels can be applied for rectal cancer ablation
- Learn how to systematically design inorganic nanoparticles for oral drug delivery