Evaluation of Acid-Base Supersolubilization Principle on Telmisartan to Lower HME Temperature
Wednesday, July 16, 2025
3:05 PM – 3:16 PM EDT
Introduction: In the present investigation, a poorly soluble acidic drug telmisartan with an intrinsic solubility of 0.1 mcg/ml in the gastrointestinal pH range of 3-7 and a melting point of 263°C is evaluated by utilizing the acid-base supersolubilization (ABS) principle. ABS is applied to increase the aqueous solubility by addition of counterbase which is meglumine, without forming a salt. Instead, the drug remains in the free acid form, but its solubility continues to increase beyond the expected maximum. ASD of telmisartan, meglumine was prepared and evaluated for dissolution rate enhancement.
Learning Objectives:
At the completion of this activity, participants will know
what is acid base supersolubilization principle
how can weakly acidic drugs and weakly basic drug interact with counter groups
