An antioxidant MOF with functional coatings for oral antibody delivery in inflammatory bowel disease

Oral biomacromolecule administration faces challenges due to the harsh gastrointestinal environment, including instability and poor intestinal absorption [1]. Here, we developed an antioxidant agent (manganese ion, Mn⁴⁺)-assembled metal‒organic framework presenting functionalized coatings consisting of an inner layer of hyaluronic acid–polyethylene glycol and an outer layer of Eudragit^® S100 for enhanced colon-targeted delivery of an anti-tumor necrosis factor-alpha antibody via the oral route. The nanosystem presented gastric resistance, enhanced disease targeting, and antioxidant activity.