Nanoparticles in Microparticles: A Potential Immunomodulatory Therapeutic System for Osteoarthritis
Wednesday, July 16, 2025
2:54 PM – 3:05 PM EDT
Introduction: Osteoarthritis (OA), a painful joint disease with no cure, affects over 600 million people worldwide, with cases projected to reach ~1 billion by 2050(1,2). Mounting evidence suggests inflammatory macrophages as key players in OA progression, thus abating their activity may advance therapy (3). Zoledronate(Zol), a bisphosphonate with anti-inflammatory potential, faces challenges like low bioavailability, rapid clearance, and cytotoxicity(4). To address this, we developed a novel nanoparticle-in-microparticle (NiM) system for sustained Zol delivery to disease-driving macrophages for OA therapy.
Learning Objectives:
At the completion of this activity, participants will know
Recognize the role of macrophages and inflammation in the progression and pain of Osteoarthritis.
Value the use of controlled delivery systems in minimizing burst release and cytotoxicity of Zol.
Appraise the NiM delivery system's potential to revamp the pharmacokinetics of Zol for OA treatment.
