A neutrophil-mediated biomimetic nanodevice for precise tumor ablation and metastasis cascade block
Wednesday, July 16, 2025
3:38 PM – 3:49 PM EDT
Introduction: The deficient discrimination of tumor cells, limited accumulation of therapeutic agents in tumor foci, and undesirable tumor metastasis result in compromised therapeutic efficacy in antitumor therapy. Herein, a biomimetic tumor discrimination nanodevice (NL-FSB) developed by harboring a pH-sensitive Fenton agent (FSB) into an activated neutrophil membrane-incorporated liposome (NL) is proposed to kill primary tumors via amplified Fenton reaction with high specificity, and prevent tumor metastasis by inhibiting the formation of circulating tumor cells (CTCs)-neutrophil clusters in circulation.
Learning Objectives:
At the completion of this activity, participants will know
Learning and discussing more about “Nanomedicine” and “Bioengineering”.
