Tech Session IV: Nanomedicine and Nanoscale Delivery (Focus: Gene)
Peptide-Lipid Conjugates for Enhancing mRNA-LNP Delivery and Colon Cancer Vaccines
Wednesday, July 16, 2025
2:04 PM – 2:29 PM EDT
Introduction: Efficient delivery of mRNA therapeutics remains a key challenge in advancing cancer immunotherapy. Lipid nanoparticles (LNPs) are widely used for mRNA delivery, but improvements in cellular uptake, endosomal escape, and cell-specific targeting are needed [1]. Here, we incorporated calreticulin (CRT)-derived peptides into LNPs to enhance mRNA delivery as the "eat me" signal. These peptide-LNPs improved delivery efficiency by 5 to 20-fold across multiple cell types and demonstrated robust immune activation in a murine colon cancer vaccine model.
Learning Objectives:
At the completion of this activity, participants will know
Upon completion, participants will be able to gain insights into peptide-functionalized LNPs
Upon completion, participants will be able to gain insights into cell-based mRNA delivery screening.
Upon completion, participants will be able to gain insights into mRNA colon cancer vaccines.
