Polymeric Mesoscale Nanoparticles Selectively Target Gene Therapies to the Kidneys

Introduction: The last decade has seen a rapid expansion of the clinical utility of gene therapies1. Many of these are focused on liver diseases, with a few exceptions(1). This is in large part due to the relative abundance of gene therapy carriers that target the liver and other accessible sites(1, 2). However, there has been very limited success in the development of kidney-targeted gene therapy carriers to treat renal diseases(1-3). Here, we focused on the development of a non-viral gene delivery tool composed of FDA-approved polymeric materials to treat chronic kidney diseases(4).