Optimizing the Biodistribution and Pharmacokinetics of Polysarcosine-based Star Dendrimers by PET/CT
Thursday, July 17, 2025
11:05 AM - 11:16 AM EDT
Location: 125
Introduction: Polyethylene glycol (PEG) is the gold standard stealth polymer in nanomedicine however concern around anti-PEG immunity has sparked the search for less immunogenic alternatives, e.g. the polypeptoid polysarcosine (pSar).[1,2] We investigate the stealth properties of pSar in vivo via a novel drug delivery platform, a pSar stealth coated dendrimer (SDend) (Fig 1a).[3] By PET/CT we compare the biodistribution and pharmacokinetics of three drug-free SDends with small, medium and large pSar stealth layers in healthy mice and compare their tumor uptake in an immunocompetent 4T1 mouse model.
Learning Objectives:
At the completion of this activity, participants will know
To identify the effect of pSar chain length on the bioD/PK of a nanoparticle for drug delivery
To understand the bioD/PK of pSar SDends in healthy and tumor bearing mice
To use in vivo PET/CT to guide the development of novel pSar SDend drug delivery systems
Amaia Carrascal Miniño, PhD – Post Doctoral Research Associate, Research Department of Imaging Chemistry & Biology, School of Biomedical Engineering & Imaging Sciences, King's College London; Aishwarya Mishra, PhD – Post Doctoral Researcher, Research Department of Imaging Chemistry & Biology, School of Biomedical Engineering & Imaging Sciences, King's College London; Thomas Floyd, PhD – Senior Scientist, Advanced Drug Delivery, BioPharmaceuticals R&D, AstraZeneca, Macclesfield, UK, AstraZeneca; Juan Pellico, PhD – Post Doctoral Research Associate, Research Department of Imaging Chemistry & Biology, School of Biomedical Engineering & Imaging Sciences, King's College London; Timothy Witney, PhD – Professor of Molecular Imaging, Research Department of Imaging Chemistry & Biology, School of Biomedical Engineering & Imaging Sciences, King's College London; Mariarosa Mazza, PhD – Associate Director, Advanced Drug Delivery, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK, AstraZeneca; Rafael Torres Martin de Rosales, PhD – Reader in Imaging Chemistry, Research Department of Imaging Chemistry & Biology, School of Biomedical Engineering & Imaging Sciences, King's College London
.jpg "Tia Gibson, MChem, MRes (she/her/hers) photo")
