Breaking barriers in endometriosis: from 3D microphysiological models to combination therapies

Introduction: Endometriosis, a disease of the female reproductive system affecting 5-10% of women of reproductive age, is associated with pelvic pain and infertility due to endometrial-like tissue growing outside the uterus, leading to scarring and fibrosis [1]. Current treatments, surgery and hormonal medication, often fail to meet patient needs. The lack of reliable experimental models has hindered the development of new treatments. Our research aims to bridge the gap between in vitro models and the development of non-hormonal treatments targeting fibrosis and pain in endometriosis (Figure 1).