Development of a new modality of transdermal platform based on nanofibers for the delivery of APIs

Introduction: The aim of this study was to develop a self-adhesive bilayer electrospun patch platform using polymeric biomaterials for the evaluation of transdermal drug delivery. PEO, PCL, and caffeine as a bioactive model compound were selected. The electrospun nanofibers were characterized using SEM, attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), and WAXS. Drug permeation was analyzed using a Franz diffusion cell, starting with a multilayer synthetic membrane and subsequently testing on human skin biopsy membranes to evaluate the best-performing candidate.