Safety evaluation of repeated microarray patch applications using a miniature pig model

Introduction: The safety of repeated microarray patch (MAP) application is critical for its development as an innovative drug delivery platform. This study evaluated the safety of hydrogel-forming, dissolving, and implantable MAPs over a four-week period using miniature pigs, a translational model with skin structure and physiological responses closely resembling those of humans [1,2]. By addressing critical knowledge gaps, this investigation provides insights into the localised and systemic effects of repeated MAP use.