Lipid nanoparticle-mediated metabolic reprogramming of dendritic cells for mRNA vaccines

Introduction: As metabolic coordination with cellular functions is crucial to immune responses, selectively modulating immune cell metabolism can achieve therapeutic goals [1]. Dendritic cells shift their focus to drive adaptive immune responses. This process demands a rapid energy supply, primarily met through glycolysis, which quickly generates ATP. Thus, ensuring adequate energy for the maturation is vital for vaccine efficacy. This study aims to design novel lipid nanoparticles with intrinsic glycolysis-stimulatory properties and efficient antigen mRNA delivery to create effective mRNA vaccines.

Michael Mitchell – Associate professor, University of Pennsylvania