Poly (β-amino ester) particles with programmable shape, stiffness, and degradation for drug release

In recent years, synthetic polymer systems have improved drug delivery through controlled crosslinking, degradation, and drug encapsulation. However, few of these polymer systems also enable the production of well-defined, nonspherical shapes at scale. Given the importance of particle shape in nanoparticle delivery and fate, we have developed a high-throughput method to fabricate drug-loaded micro- and nanoparticles with controllable shape, size, and material properties [1,2]. Further, we investigate the use of such particles for adoptive cell transfers and soft micro-robotics.