Tech Session V: Nanomedicine and Nanoscale Delivery (Focus: Oral)
NAC-based Ionic Liquids for GLP-1 Delivery: A Mechanistic Understanding of In Vivo Performance
Thursday, July 17, 2025
10:29 AM - 10:54 AM EDT
Location: 121 B/C
Introduction: Currently, oral delivery of peptides requires formulations with high concentrations of permeation enhancer (PE) to promote absorption, and fast onset of action to mitigate dosing condition [1]. For this purpose, we have developed a salcaprozate-based ionic liquids (IL), namely choline salcaprozate (CHONAC), for oral delivery of a glucagon-like peptide-1 (GLP-1) analogue via gastric absorption.
Learning Objectives:
At the completion of this activity, participants will know
Mechanistic understanding of the in vivo performance of ionic liquids and liquid-based formulations
How to improve the performance of ionic liquids and liquid-based formulations in oral GLP-1delivery
Rene Rebollo, n/a – Associate Scientist, Novo Nordisk; Lasse Blaabjerg, n/a – Senior Scientist, Novo Nordisk; Damiano La Zara, n/a – Senior Scientist, Novo Nordisk; Henrik Pedersen, n/a – Principal Scientist, Novo Nordisk; Philip Sassene, n/a – Scientific Director, Novo Nordisk
