Tech Session V: Nanomedicine and Nanoscale Delivery (Focus: Oral)
Novel Dual-layer Capsule Coating Method for Targeted Colon Delivery of Aqueous Probiotic Suspensions
Thursday, July 17, 2025
11:27 AM – 11:38 AM EDT
Introduction: Probiotics can balance gut microbiota, support immunity, and alleviate GI disorders, yet delivering enough live cells remains challenging. Freeze-drying significantly reduces probiotic viability, limiting the number of live cells that reach the colon. While aqueous formulations can achieve 95% survival [1], but degrade prematurely in gastric conditions. Hence, innovative delivery systems are urgently needed to preserve probiotic viability and enable targeted colon release. A novel dual-layer capsule coating method was developed in this research to achieve aqueous probotic suspension delivery.
Learning Objectives:
At the completion of this activity, participants will know
Understand the rationale behind capsule coating and how this design maximizes probiotic viability.
Recognize the importance of pH-sensitive polymers for protecting probiotics in GI environments.
Identify key considerations that influence capsule integrity, porosity, and targeted release.
