Tech Session V: Nanomedicine and Nanoscale Delivery (Focus: Oral)
Phytosomal soft nanoparticles for enhanced biopharmaceutical and antioxidant potential of flavonoids
Thursday, July 17, 2025
11:49 AM – 12:00 PM EDT
Introduction: Silymarin (SLM) and curcuminoids (CURs) are polyphenolic compounds that are majorly utilized in large doses for the management of liver-related diseases. However, its poor oral bioavailability because of modest solubility, first-pass metabolic process, dissolution, poor permeation and dose-related side effects hampered its effectiveness. Therefore, double-loaded phytosomal soft nanoparticles (SC PSNPs) were synthesized to increase the solubility, dissolution, bioavailability, and synergistic antioxidant performance of SLM and CURs.
Learning Objectives:
At the completion of this activity, participants will know
Demonstration of phytosomal nanoparticles of flavonoid for enhancing their antioxidant performance.
Describe the co-entrapment of silymarin and curcuminoids in a single phytosomal nanoparticles.
Discuss the pharmacokinetic benefits among double loaded and single loaded phytosomal formulations.
