A successful application of high-loading amorphous solid dispersions in HME & Additive Manufacturing
Thursday, July 17, 2025
5:57 PM - 6:08 PM EDT
Location: 125
Introduction: The combination of HME and 3DP has enabled the design of complex ASD tablet structures to control drug release. To fully achieve dose variation and compact API combinations [1,2,3], maximizing the drug loading is an essential but challenging aspect, as highly-loaded ASDs are prone to recrystallization during storage and dissolution. This study focuses on understanding the behavior and processability of a challenging 70% drug-loaded ASD fabricated via 3DP as an oral dosage form.
Learning Objectives:
At the completion of this activity, participants will know
Comprehend the framework for processing highly-loaded ASDs of BCS Class II drugs using HME and 3DP.
Learn how tablet properties influence release rate tuning in highly-loaded tablets made via 3DP.
Susanna Abrahmsén-Alami – Sustainable Innovation and Transformational Excellence, Pharmaceutical Technology and Development, Operations,, AstraZeneca, Gothenburg, Sweden; Jonathan Booth – New Modalities and Parenteral Product Development, Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield, United Kingdom; Vinith Mohan – PhD Student, Research Center Pharmaceutical Engineering; Thomas Rillman – Head of Business Development Functional Excipients, IOI Oleo; Sharareh Salar-Behzadi – Key Researcher, Research Center Pharmaceutical Engineering; Martin Spoerk – Scientific Leader, Research Center Pharmaceutical Engineering; Elisa Goetzinger – Student, University of Graz; Josip Matić – Senior Scientist, Research Center Pharmaceutical Engineering
