Tech Session VI: Nanomedicine and Nanoscale Delivery (Focus: Gene)
Hybrid polymer-lipid nanoparticles as innovative transfection vectors for microRNA delivery
Thursday, July 17, 2025
5:24 PM – 5:35 PM EDT
Introduction: MicroRNAs (miRNAs) regulate various physiological and pathological processes [1,2]. Thus, several therapeutic strategies based on viral vectors and non-viral transfection agents for miRNAs delivery have been developed. However, viral vectors face limitations due to safety issues and high costs, while commercial lipidic and polymeric transfection agents suffer from poor stability, incomplete loading efficiency, and uncontrolled release kinetics [3]. To address these challenges, novel polymer-lipid nanoparticles (H-NPs) were designed as innovative transfection agent for miRNA delivery.
Learning Objectives:
At the completion of this activity, participants will know
Understand H-NPs design and advantages as novel transfection vectors for efficient miRNA delivery
Explore the role of H-NPs in cardiac regeneration via AHCFs reprogramming and CMs proliferation
