Nano meets micro: Enhanced dermal delivery of lipophilic tocotrienol nanoemulsion using microneedles
Thursday, July 17, 2025
5:57 PM – 6:08 PM EDT
Introduction: Being a potent antioxidant, anti-inflammatory and UV protective agent, palm oil tocotrienol-rich fraction (TRF) offers excellent dermal benefits. But its high lipophilicity hinders skin permeation despite in nanoformulations. Dissolving microneedles (MN) that pierce through the skin may enhance TRF delivery. To maximise the TRF delivery with MN designs, microfabrication using 3D printing (3DP) can provide a flexible solution. Thus, this study aims to improve dermal delivery of TRF by combining nanoemulsion (NE) and 3DP MN.
Learning Objectives:
At the completion of this activity, participants will know
Explore the enhanced dermal delivery of highly lipophilic TRF by integrating NE with 3DP MN
Understand the design parameters to improve the dimensional resolution of 3DP MN
Compare the skin permeation profiles of NE-MN vis-a-vis TRF and NE alone
