Novel Solid Lipid Nanoparticles-Enriched Hydrogels for Topical Delivery of Anti-Ageing Glutathione
Thursday, July 17, 2025
6:19 PM – 6:30 PM EDT
Introduction: Skin ageing is driven by oxidative stress caused by reactive oxygen species (ROS), with ultraviolet A (UVA) radiation contributing up to 80% of extrinsic skin damage. L-Glutathione (GSH), a potent antioxidant, shows promise in mitigating UVA-induced oxidative stress. However, its topical application is hindered by chemical instability and limited permeation across the stratum corneum (SC). This research focuses on developing a novel solid lipid nanoparticle (SLN)-enriched hydrogel to enhance GSH stability, skin penetration, and sustained release for anti-ageing applications.
Learning Objectives:
At the completion of this activity, participants will know
Formulate and characterize SLNs-enriched hydrogels for enhanced topical delivery of GSH.
Evaluate the stability and penetration efficacy of the hydrogel across the SC.
Assess the antioxidant efficacy of the hydrogel against UVA-induced oxidative stress.
