Reconstructed Human Patient Dynamic Models for Engineering Targeted Therapeutics for Aneurysms

Introduction: An aneurysm is an abnormal bulge in a blood vessel wall caused by weakening. Its rupture can lead to a subarachnoid hemorrhage, a life-threatening emergency. Treating unruptured aneurysms with minimally invasive surgeries involve significant risks, when there is no medical treatment available (1-3). Here, we present patient-specific reconstructed models that simulate the biophysical features of high-risk aneurysms, including recirculating blood flow and damaged vessel walls. These models demonstrate the critical differences in designing therapeutic carriers for human vs animal models (4,5).