Tech Session VII: Alternative Methods to Animal Testing II
Development of innovative 3D colorectal cancer models as preclinical tools for drug screening
Friday, July 18, 2025
9:05 AM - 9:16 AM EDT
Location: 123
Introduction: Therapeutic management in colorectal cancer (CRC) patients remains highly ineffective. Thus, the development of improved preclinical models that better resemble the in vivo tumor microenvironment (TME), with higher predictive properties, is fundamental to successfully developing novel treatments. This project aims to establish a 3D spheroid model that recapitulates CRC, a 3D model that mimics intestinal tissue under dynamic flow conditions, and a combination of both models.
Learning Objectives:
At the completion of this activity, participants will know
Understand the development and characterization of advanced 3D Models;
Recognize the applications of 3D models in the screening of new delivery systems;
Sofia Costa – PhD Student, i3S – Institute for Research and Innovation in Health, University of Porto, Portugal; Juliana Viegas – Postdoctoral Fellow, i3S – Institute for Research and Innovation in Health, University of Porto, Portugal; Marshall S. Padilla – Postdoctoral Fellow, School of Engineering and Applied Science, University of Pennsylvania; Amanda Murray – PhD Student, School of Engineering and Applied Science, University of Pennsylvania; Michael J. Mitchell – Principal Investigator, School of Engineering and Applied Science, University of Pennsylvania; Bruno Sarmento – Principal Investigator, i3S - Institute for Research and Innovation in Health, University of Porto, Portugal; Catarina Pereira – Associate Research, i3S - Institute for Research and Innovation in Health, University of Porto, Portugal
