Nanoparticle Functionalization to Target the Circadian Clock in Alzheimer’s Disease

Introduction: Disruptions in the central circadian clock (CC) have been shown to accelerate Alzheimer’s disease pathogenesis [1,2]. While CC-targeting molecules have shown efficacy in preclinical models, their clinical success is limited by poor brain penetration due to the blood-brain barrier (BBB) and dose timing [1,3]. Nanoparticles (NPs) offer a potential solution by tunable drug release and by improving brain permeability through passive permeation and active active transport mechanisms when functionalized with brain targeting moieties.