Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines

Introduction: RNA vaccines have revolutionized global health, with over billion doses administered globally (1). Enhancing their potency could improve immunity at lower doses, reducing manufacturing challenges and side effects. Ionizable lipids are key to boosting vaccine potency by facilitating endosomal escape, enhancing immunogenicity, and improving tolerability. While current lipids like SM-102 set benchmarks, advancements beyond FDA-approved formulations remain limited. To address this, we aimed to develop more potent ionizable lipids to enhance mRNA transfection, improving vaccine safety and efficacy.