Tech Session VII: Gene Delivery and Gene Editing IV
An Optimized Polymeric Delivery Platform for Pulmonary mRNA Vaccines
Friday, July 18, 2025
9:38 AM – 9:49 AM EDT
Introduction: Pulmonary mRNA vaccines have the potential to elicit mucosal immunity in the respiratory tract, providing significant protection against respiratory infectious diseases. While approved mRNA vaccines using lipid nanoparticles (LNPs) as carrier systems effectively induce systemic immunity via intramuscular injection, the pulmonary delivery of lipid-based carriers is often hindered by poor mucus permeability [1]. Here, we developed a polymeric platform integrating biodegradable polymers, poly(lactic-co-glycolic) acid and poly (β-amino esters), for efficient mRNA vaccine delivery to the lungs.
Learning Objectives:
At the completion of this activity, participants will know
Address the challenges of mRNA transfections into antigen presenting cells.
Evaluate the differences between polymeric and lipid-based system in mucus penetration.
Develop a delivery platform suitable for pulmonary mRNA vaccines.
