Tech Session VII: Nanomedicine and Nanoscale Delivery (Focus: Bioengineering)
Tendon-derived ECM enables percutaneous delivery of iMSC-SCX+ for tendon defect healing
Friday, July 18, 2025
9:27 AM – 9:38 AM EDT
Introduction: Current tendinopathy treatments often lead to incomplete healing, leading to re-rupture and failed tendon function restoration [1]. Decellularized extracellular matrix (ECM) mimics the native tissue, supporting regeneration with tissue-specific biochemical cues [2], while exhibiting thermoresponsive gelation to form a 3D scaffold. The objective of this study was to develop an injectable hydrogel from decellularized tendon ECM (tECM) as a local percutaneous scaffold for tenogenic scleraxis (SCX)-overexpressing human induced mesenchymal stem cells (iMSCSCX+) to enhance tendon healing.
Learning Objectives:
At the completion of this activity, participants will know
Understand the biomechanical properties of tECM for potential cell delivery scaffold.
Evaluate the enhanced tenogenic effects of tECM on iMSCSCX+.
Explain feasibility and strengths of tECM for locoregional treatment of tendon diseases.
