Modulating the Response of Neurons and Glia Cells for Spinal Cord Injury Recovery

Introduction: Spinal cord injuries (SCI) result in significant functional deficits due to limited intrinsic regeneration of neurons and glia. This study addresses the dual challenge of promoting neuroregeneration and mitigating neuroinflammation through genetic interventions. The primary objective is to develop gold-complexed antagomir-155 (GP-155) to target miR-155, a regulator of inflammation and macrophage polarization [1, 2]. By suppressing miR-155 activity, we aim to facilitate a conducive environment for neuronal repair and recovery to the final aim of advancing therapeutic options for SCI.

.

Cristina Casadidio – Post doc researcher, University of Camerino; Piera Di Martino – Professor, University of Chieti; Sofia Figoli – PhD student, Leeds University; Nikita Gamper – Professor, Leeds University; Maria Rosa Gigliobianco – Post doc researcher, University of Chieti; Ronaldo Ichiyama – Professor, Leeds University; Saniya Salathia – PhD student, University of Camerino