Xkr8 Knockdown Enhances Chemotherapy Efficacy Through Modulating Tumor Immune Microenvironment

Introduction: Scramblase Xkr8 regulates phosphatidylserine (PS) externalization during cell apoptosis, a critical process for mediating tumor immunosuppression through recognition by immune cells. Absence of PS on the surface of apoptotic cells impairs their recognition and phagocytosis by phagocytes. Targeting Xkr8 in combination with chemotherapy has been shown to increase antitumor immune response. Here, we further evaluated the strategy under conditions representing clinical features and elucidated how targeting Xkr8 modulates tumor immune microenvironment (TIME) through single-cell characterization.

Yuang Chen – Post doc, Massachusetts Institute of Technology; Yixian Huang – Post doc, University of Pittsburgh; Song Li – Professor, University of Pittsburgh