Extracellular Vesicle Lipid Rafts Profiling as a Blueprint for Targeted EV-Mimetic Therapies

Introduction: Cells secrete extracellular vesicles (EVs), nanoparticles enclosed by a lipid bilayer, to mediate cell-to-cell communication, facilitating interactions between donor and recipient cells within (but not limited to) tumour microenvironment. Yet, little is known about the interplay between EV lipid membrane composition and selectivity for target cells. In this study, we investigated differences in the lipid composition of EVs released from cancerous and non-cancerous breast epithelium to define potential key lipids to be translated into triple-negative BC-specific drug delivery formulation.

Carolina Lopes Silva, UNIGE – Master Student, University of Geneva; Isabel Meister, UNIGE – Research and Teaching Fellow, University of Geneva; Julien Boccard, UNIGE – Research Associate, University of Geneva; Stoyan Tankov, UNIGE – Post-Doc, University of Geneva; Olivier Jordan, UNIGE – Maître d'enseignement et de recherche, University of Geneva; Paul Walker, UNIGE – Professeur ordinaire, University of Geneva; Serge Rudaz, UNIGE – Full Professor, University of Geneva; Gerrit Borchard, UNIGE – Professeur ordinaire, University of Geneva