Skip to main content
CRS 2025 Annual Meeting & Exposition Main banner
Final Program


CRS Abstract Guide

Skin and Mucosal Delivery

Tech Session I: Skin and Mucosal Delivery I

Combination of liposomes and ultrasound for noninvasive rapid transdermal cosmeceutical delivery

Tuesday, July 15, 2025
11:27 AM - 11:38 AM EDT
Location: 119 B
Introduction: The growing demand for healthy-looking skin calls for a noninvasive rapid method to enhance absorption of hydrophilic (LogP < 1) and macromolecular (MW>500) cosmeceuticals limited by the stratum corneum (SC)[1]. Liposomes, as star-level transdermal carriers, can also act as cavitation nuclei under ultrasound sonication. Their oscillation and collapse generate microstreams, shock waves or microjets, disrupting the SC lipid bilayer to enhance penetration[2]. Here, we proposed a strategy combining ultrasound-responsive liposomes with ultrasound for noninvasive rapid delivery of hydrophilic and macromolecular cosmeceuticals.

Learning Objectives:

At the completion of this activity, participants will know
  • Demonstrate the feasibility of cavitation-mediated transdermal delivery.
  • Evaluate the differences between cavitation-mediated transdermal delivery and passive penetration.
Nianou Wang – Staff, Shenzhen Accompany Tech co., ltd; Ke Li – Staff, Shenzhen Accompany Tech co., ltd; Huan Liang – Staff, Shenzhen Accompany Tech co., ltd; Jingfeng Bai – Research Fellow, Shanghai Jiao Tong University; Ji Xiang – Senior Engineer, Shanghai Jiao Tong University