MeltPrep Presentation

The MeltPrep Slider enables thermal analysis in minutes. Diagrams such as DSC thermograms contain numerical values of quantities that are often difficult for developers to transfer to their applications. The approach introduced here enables assessments within minutes using the most natural senses provided by nature: our eyes and hands. It relies on a heated plate with a linear temperature gradient ranging from 50 to 300°C, with all temperatures accessible at all times. A microscope slide holds the sample and is moved to the desired temperature. This setup allows for rapid visual and haptic feedback of sample materials within just a few minutes. Touching is done indirectly using a spatula while comparing it to materials with known viscosities and transition temperatures. Navigating the complexities of amorphization and temperature-dependent recrystallization of active pharmaceutical ingredients is greatly enhanced by this visual feedback. Further examples to illustrate the determination of process temperatures (molding, extrusion) and degradation