Biocatalytic Nanobots: Modulating Oxidative Stress in Cellular Models of Inflammatory Bowel Disease
Wednesday, July 16, 2025
11:05 AM - 11:16 AM EDT
Location: 119 B
Introduction: Inflammatory bowel disease (IBD) is a chronic disorder marked by elevated levels of reactive oxygen species (ROS), which exacerbate local inflammation and lead to intestinal mucosal damage (1). Intelligent nanotechnologies, such as biocatalytic nanobots (NBs), offer targeted strategies to reduce oxidative stress (2). This study investigates a self-propelled NB designed to neutralize extracellular ROS and maintain biocompatibility with colonic cells, paving the way for future integrations of bioactive compounds to address intracellular stress further.
Learning Objectives:
At the completion of this activity, participants will know
Describe the mechanism of biocatalytic nanobots that neutralize extracellular ROS.
Analyze the correlation between NB propulsion and its functionality in ROS-enriched environments.
Assess the biocompatibility and broader therapeutic potential of nanobots in colon cell models.
André Mayer – MSc Student, CBQF - Centro de Biotecnologia e Química Fina, Universidade Católica Portuguesa; Manuela Pintado – Professor, CBQF - Centro de Biotecnologia e Química Fina, Universidade Católica Portuguesa; Celso Reis – Professor, i3S—Instituto de Investigação e Inovação em Saúde; Ana Sousa – PhD Student, CBQF - Centro de Biotecnologia e Química Fina, Universidade Católica Portuguesa
