Blood-brain barrier targeted nanoparticles for peptide delivery to glioblastoma.

Introduction: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults [1]. One of the primary challenges in treating GBM is the inability to effectively target malignant cells outside the tumor core, often hidden behind the blood-brain barrier (BBB). In this study, we developed Lipid Nanoparticles (LNPs)[2] delivering model peptides targeting the extracellular matrix of glioma cells. These LNPs could successfully accumulate in brain tumors and release their payload after crossing the BBB, providing a suitable target for new therapies against GBM.