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Industry Session
Workshop

Workshop: Recent Advances in Oral Peptide Delivery – From Molecule to Market

Monday, July 14, 2025
8:00 AM – 4:30 PM EDT

Sponsored By Quotient Sciences, Frontiers Media S.A., Genentech, Inc., Janssen Phamaceutica NV, a Johnson & Johnson Company, Protagonist Theraputics, Bristol Myers Squibb Co., Novo Nordisk

Systemic delivery of peptides by the oral route is now a reality with multiple products on the market and many more in development. Attendees will learn of the latest advances in oral peptide delivery and its future directions from world leading academics and industry leaders who have successfully taken oral peptide products from preclinical development to translation into the clinic and market launch. Topics covered include fundamental mechanisms, peptide engineering, oral peptide biopharmaceutics, novel drug delivery systems and their clinical development. Insights and learnings will be shared on how to navigate the unique challenges oral peptide programs present and future directions of the field.

Learning Objectives:

At the completion of this activity, participants will know
  • Learn the latest developments in our understanding of oral peptide biopharmaceutics
  • Hear the latest progress on the clinical development of oral products from industry leaders
  • Share insights and learnings in managing the transition from preclinical to clinical development of oral peptide products

Presentations:

  • 8:00 AM – 8:30 AM EDT
    Welcome & Introductions
  • 8:30 AM – 9:00 AM EDT
    An assessment of the trends in oral peptide administration

    Chair and Speaker: David J. Brayden, PhD (he/him/his) – University College Dublin

  • 9:00 AM – 9:30 AM EDT
    Characterization of macrocyclic peptide drug interactions with bile salts and biorelevant colloids in the context of oral delivery

    Speaker: Tahnee Denning – Genentech

  • 9:30 AM – 10:00 AM EDT
    Overcoming barriers to oral macromolecule delivery: What is coming next

    Chair and Speaker: Stephen T. Buckley, PhD – Novo Nordisk

  • 10:00 AM – 10:30 AM EDT
    Coffee Break
  • 10:30 AM – 11:00 AM EDT
    Applications of PBPK Modelling in Oral Peptide Delivery

    Speaker: Ricardo Diaz de Leon Ortega – Quotient Sciences

  • 11:00 AM – 11:30 AM EDT
    Pre-clinical screening of permeation enhancers for oral peptide administration in oral dosage forms: update on GI-ORIS

    Speaker: Tom Vonderlach – Vivtex Corporation

  • 11:30 AM – 12:00 PM EDT
    Employing Endogenous Pathways for Efficient Paracellular Uptake of Peptide and Vesicular Transcytosis of Protein Therapeutics

    Speaker: Randall Mrsny – University of Bath

  • 12:00 PM – 12:30 PM EDT
    Roundtable 1

    Speaker: David J. Brayden, PhD (he/him/his) – University College Dublin

    Speaker: Randall Mrsny – University of Bath

    Speaker: Neil Mathias – Bristol Myers Squibb

  • 12:30 PM – 1:30 PM EDT
    Lunch Break
  • 1:30 PM – 2:00 PM EDT
    The development of the oral macrocycle, MK-0616, for treating hypercholesterolemia

    Speaker: Douglas Johns – Merck Research Laboratories

  • 2:00 PM – 2:30 PM EDT
    Enabling Oral Delivery of Peptides through Molecular and Formulation Design: A J & J Perspective

    Speaker: Sumit Arora, PhD – Johnson and Johnson Innovative Medicine

  • 2:30 PM – 3:00 PM EDT
    An Oral Macrocycle to Access Intracellular RAS Targets in Cancer: The Road to Formulation Design of LUNA18 for Phase I Trials

    Speaker: Takamitsu Ueto – Chugai Pharma

  • 3:00 PM – 3:30 PM EDT
    Coffee Break
  • 3:30 PM – 4:00 PM EDT
    BIONND™, a device technology for the administration of peptides across the stomach

    Speaker: Karsten Lindhart – Biograil Ltd

  • 4:00 PM – 4:30 PM EDT
    Roundtable 2

    Speaker: Andy Lewis, BPharm (Hons) PhD (he/him/his) – Quotient Sciences

    Speaker: Manuel Sanchez-Felix, PhD (he/him/his) – Halozyme

    Speaker: Stephen T. Buckley, PhD – Novo Nordisk

    Speaker: Mo Masjedizadeh – Protagonist Therapeutics