(147) GPNMB as an Orthobiologic for Bone Regeneration and Spinal Fusion for an Osteoporotic Rat Model

Introduction: Osteoinductive agents are essential for bone healing in orthopaedic procedures. Although autogenous bone grafting is the gold standard, it is limited by infection, pain, and fractures. Osteoactivin (GPNMB), a transmembrane glycoprotein, is a promising orthobiologic that promotes osteoblast differentiation, matrix mineralization, and bone formation while reducing inflammation. This study evaluates the potential role of GPNMB in spinal fusion surgery using an FDA-approved collagen sponge and a postmenopausal osteoporotic rat model to assess its clinical potential for enhanced bone repair.