(178) Hybrid vesicles for enhancing intracellular uptake of siRNA

Introduction: Extracellular Vesicles (EVs) are nano-vesicles surrounded by a phospholipid bilayer with varying dimensions, transmitting signals from their parental cell towards target cells within the microenvironment and up to distant organs. EVs may be considered ideal vehicles for encapsulated drug delivery by guaranteeing a significant increase in therapeutic efficacy, greater specificity and limited systemic side effects. In the last decade, using bio-engineered EVs to encapsulate and deliver cytotoxic molecules has shown encouraging results in preclinical settings.