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Manufacturing and Process Scale-Up

(272) Impact of Polymer Concentration on Metformin HCl Tablet Properties and Extended-Release Profiles

Introduction:

The formulation of extended-release (ER) tablets is a critical aspect of pharmaceutical development, particularly for a highly water-soluble drug like metformin HCl. This study explores the use of high viscosity Hypromellose (HPMC K100M, AnyCoat CN10T) in a direct compression (DC) metformin HCl 500 mg ER formulation to characterize tablet properties and the impact of polymer levels on the drug release profile of a highly soluble drug.

Learning Objectives:

  • Explore the use of high viscosity Hypromellose in direct compression metformin ER formulation
  • Characterize the impact of polymer levels on drug release profile of highly soluble metformin