(273) Next-Generation Lipid Nanoparticles: Advancing Ionizable and PEG-Free Shielding Lipids
Introduction: Lipid Nanoparticles (LNPs) have revolutionized nucleic acid delivery by enhancing stability, efficiency, and controlled release [1]. However, the reliance on polyethylene glycol (PEG) raises concerns about immune-related side effects and reduced efficacy with repeated dosing—known as the "PEG dilemma" [2] Additionally, ionizable lipids play a crucial role in optimizing payload versatility, delivery efficiency, and safety. This study explores innovative strategies to address these challenges, paving the way for next-generation LNP formulations.
Learning Objectives:
Upon completion, participants will be able to understand the role of ionizable lipids in LNPs
Upon completion, participants will be able to explore different genetic payload delivery
Upon completion, participants will be able to evaluate alternative PEG replacement polymers
