(279) Creating a novel implant for controlled release to improve radiation sensitivity in prostate cancer

Introduction: Gold nanoparticles (AuNPs) are promising radiosensitisers but face issues like instability and poor uptake. RALA, a cell-penetrating peptide, enhances AuNP internalisation, achieving effective radiosensitisation at lower concentrations than most studies. AuNPs can reduce radiation dose and off-target toxicity, but maintaining their presence throughout radiotherapy often requires repeated injections, which may burden patients. To overcome this, RALA-AuNP-loaded implants were developed for sustained, prolonged release of radiosensitising AuNPs, ensuring consistent treatment efficacy.