(284) Evaluation of Vaccine Induced Antitumor Response of Cationic Nanoparticles in Colorectal Cancer

Introduction: The incidence of colorectal cancer (CRC) ranks third worldwide, while the mortality rate ranks second. Cancer vaccines alone are usually ineffective due to immunosuppressive nature of tumor microenvironment (TME). We have previously shown that cationic nanoparticles (NPs) of PAMAM dendrimers and PLGA (PMG-5 NPs) could significantly enhance the antitumor response of a melanoma vaccine [1]. In this study, we proposed the delivery of PMG-5 NPs in the TME in addition to CRC vaccine and immune checkpoint blockade (ICB) therapy can augment the antitumor efficacy of CRC vaccine in a mouse CRC model.