(301) Drug-loaded cyclodextrin-based polymers to treat pulmonary infections

Introduction: Infections caused by drug-resistant pathogens pose a global healthcare challenge that requires innovative treatment solutions [1]. Cyclodextrin (CD)-based polymers enhance drug solubility, stability, and controlled release by utilizing the host-guest complexation properties of CDs [2-4]. This study focuses on developing water-soluble CD polymers to encapsulate hydrophobic antibiotics to be delivered specifically to the lungs. We investigated the encapsulation of linezolid, a poorly water-soluble antibiotic commonly used to treat infections caused by drug-resistant gram-positive bacteria.