(324) pH-sensitive Ionizable Lipid-based Nanoparticles for siRNA delivery to Liver

Introduction: Lipid nanoparticles (LNPs) have now become a mature system for siRNA delivery, which avoid degradation and overcome multiple physiological barriers. LNPs can target liver tissues due to the formation of biomolecular corona and the ApoE effect, transporting them to hepatocytes via LDL receptor mediated endocytosis. Currently, while the composition and fabrication of LNPs are well-defined, much remains to be learnt regarding the structure-activity relationship of ionizable lipids in nucleic acid delivery, especially pH-sensitive ionizable lipids.