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Nanomedicine and Nanoscale Delivery (Focus Group - NND)

(350) Targeting alveolar macrophages with sialic acid-decorated liposomes

Introduction: Pulmonary inflammation is a major cause of lung damage and death. Macrophages, key immune cells in alveoli, polarize from M2 (anti-inflammatory) to M1 (pro-inflammatory) upon pathogen entry. Acetylneuraminic acid (Neu5Ac) is a type of sialic acid found in various organisms, including viruses, is able to be recognized by receptors in certain immune cells, such as macrophages. This study evaluates the internalization and capacity to modulate macrophages polarization by sialic acid-decorated liposomes administered via nebulization in an in vivo LPS-induced inflammation model.

Learning Objectives:

  • Sialic acid liposomes target alveolar macrophages to treat lung inflammation effectively.
  • Explore the potential of liposomes to modulate macrophage polarization during pulmonary inflammation
  • Evaluate the effectiveness of nebulized delivery in targeting lung inflammation.
Naiara Ieza Benedetti – PhD researcher, University Federal of Goiás; Nathalia Correa – Postdoctoral researcher, University Federal of Goiás; Marcília Gonçalves – Researcher, University Federal of Goiás; Tácio Gonçalves Hayasaki Gonçalves Hayasaki – PhD researcher, University Federal of Goiás; Eliana Lima – Faculty, University Federal of Goiás