(441) Development of an in situ gelling ocular vehicle: A design of experiments (DOE) approach
Introduction: In situ gelling eye drops have been explored for their promise to extend residence time of topical therapies on the eye through a number of gelation mechanisms.1-3Previous work in our lab demonstrated synergistic interactions between two ion-activated polymers (gellan gum (GG) and carrageenan (CG)) for the development of an in situ gelling ocular drug delivery vehicle (ODDV). The purpose of this work was to expand on this formulation with the addition of the mucoadhesive element, hyaluronan (HA) to optimize an ODDV using a space filling mixture design (SFMD) DOE approach.
Learning Objectives:
Explain the advantages of the ODDV in increasing ocular residence time
Understand how a DOE approach reduces the design space and allows for targeted testing of factors.
Evaluate different formulations to determine which combination is optimal for sustained delivery.
