(465) The influence of PEGylated surfactants on the colonic absorption of celecoxib from nano-emulsion
Introduction: Oil-in-water (O/W) nano-emulsions (NEs) mainly consists of oil and surfactant, forming nano-sized droplets after emulsifying in aqueous phase. Many surfactants contain polyethylene glycol (PEG) chains, which affect surface properties by positioning outward. Unlike small intestinal absorption, the low-lipase environment of colon allows droplet to remain intact, highlighting the role of the surface of the NEs1.Our aim is to assess the influence of PEGylated surfactants on the release, mucus permeation and colonic absorption of celecoxib (CCX, a BCS II drug) from NEs.
Learning Objectives:
know the correlation between in vitro drug release, mucus permeation and colonic absorprtion of NEs
gain the skills of making emulsions with varying surfactant amounts but the same droplet sizes
