(467) Zero-Order Drug Release from Push-Pull Osmotic Tablets in Varying Dissolution Media
Introduction: Push-pull osmotic pump (PPOP) tablets are generally unaffected by physiological variations and show consistent release in different dissolution media (pH, hydrodynamics, ionic strength). Marketed PPOP tablets are typically manufactured using solvent granulation for both layers, posing processing challenges and safety concerns. A direct compression (DC) push layer was developed to address these issues. This study evaluates the effects of dissolution conditions and media on release profiles of PPOP tablets utilizing a DC push layer, while assessing the impact of a DC or granulated pull layer.
Learning Objectives:
Understand the impact of varying media and pull layer manufacture process on the release profile.
